HCID 69780447, 화합물 → HCID 86587005, 화합물

HRID 1266848노트

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HRID 1266848 반응식
C(O[C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5])C>NCCO>[OH:5][CH2:4][CH2:6][NH:7][C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5]

참가 물질

3

반응물 1

HCID 69780447HCID 69780447, 화합물

생성물 1

HCID 86587005HCID 86587005, 화합물수율 110.5%

시약·촉매·용매 1

HCID 700Ethanolamine용매

실험 절차

A solution of 5-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid ethyl ester (Example 23) (35mg) in 2-amino-ethanol (1 mL) was stirred at 50° C. for 4 h. The mixture was partitioned between H2O and EtOAc. The organic layer was dried and evaporated in vacuum, and the residue was triturated with EtOAc to give the title compound (20 mg) as light-yellow solid.

후처리

  1. customThe mixture was partitioned between H2O and EtOAc
  2. customThe organic layer was dried
  3. customevaporated in vacuum
  4. customthe residue was triturated with EtOAc

출처 및 근거

ORD 기록
ord-4d3393e9a666440b84cd00455139561c
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06548495B2

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