Dimethylformamide → HCID 18544790, 화합물

HRID 1266924

반응식

HRID 1266924 반응식
[F:1][C:2]([F:14])([C:5]([F:13])([F:12])[C:6]([F:11])([F:10])[CH:7]([F:9])[F:8])[CH2:3][OH:4].CN(C=O)C.C(=O)([O-])[O-].[K+].[K+].[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29](F)[N:28]=1>O>[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([O:4][CH2:3][C:2]([F:14])([F:1])[C:5]([F:12])([F:13])[C:6]([F:10])([F:11])[CH:7]([F:8])[F:9])[N:28]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 96412,2,3,3,4,4,5,5-Octafluoro-1-pentanolHCID 11430Potassium CarbonateHCID 739342,6-Difluoropyridine

생성물 1

HCID 18544790HCID 18544790, 화합물수율 88.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A reaction flask was loaded with 2,2,3,3,4,4,5,5-octafluoropentanol (16.1 g), DMF (42 ml), anhydrous potassium carbonate (9.6 g), followed by stirring at room temperature for one hour. To this mixture, 2,6-difluoropyridine (8.0 g) was dropwise added. The temperature was raised to 60° C., and the mixture was stirred for four hours. The heating was stopped, and water was added to the reaction mixture, followed by extraction with ethyl acetate. The extract was condensed by an evaporator to give 2-fluoro-6-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-pyridine (20 g).

후처리

  1. temperatureThe temperature was raised to 60° C.
  2. stirringthe mixture was stirred for four hours
  3. extractionfollowed by extraction with ethyl acetate
  4. customcondensed
  5. customby an evaporator

출처 및 근거

ORD 기록
ord-330d9699c2c744848e0eb9f9573a1571
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06551682B1

연결된 노트

불러오는 중…