1,2-Naphthoquinone → HCID 135754684, 화합물

HRID 1266929노트

반응식

HRID 1266929 반응식
[C:1]1(=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]1=O.[NH:13]([C:15]1[C:20]([C:21]([F:24])([F:23])[F:22])=[C:19]([O:25][CH3:26])[N:18]=[C:17]([CH3:27])[N:16]=1)[NH2:14]>C(O)(=O)C>[CH3:26][O:25][C:19]1[N:18]=[C:17]([CH3:27])[N:16]=[C:15]([N:13]=[N:14][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:1]=2[OH:12])[C:20]=1[C:21]([F:24])([F:23])[F:22]

참가 물질

4

반응물 2

HCID 106671,2-Naphthoquinone2회HCID 18544800HCID 18544800, 화합물

생성물 1

HCID 135754684HCID 135754684, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
110 °C

실험 절차

Then, a flask was loaded with acetic acid (50 ml) and 1,2-naphthoquinone (2.9 g), and the temperature was raised up to 110° C. with stirring to dissolve 1,2-naphthoquinone. To this mixture, 4-hydrazino-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine (4 g) was added in 30 minutes. After stirring at 110° C. for 3 hours, the heating was stopped and left to cool. The reaction mixture was filtrated. The filtrated crystals were recrystallized with dioxane to give crystals, which were then filtrated and dried to give intended crystals (2.3 g).

후처리

  1. stirringAfter stirring at 110° C. for 3 hours
  2. waitleft
  3. temperatureto cool
  4. filtrationThe reaction mixture was filtrated
  5. customThe filtrated crystals were recrystallized with dioxane
  6. customto give crystals, which
  7. filtrationwere then filtrated
  8. customdried
  9. customto give

출처 및 근거

ORD 기록
ord-f9b3d5abc5944628b853fa1d429791b3
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06551682B1

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