Cyclododeca-4,8-diene-1-carbaldehyde → 1-(4,8-Cyclododecadienyl)-2-methyl-1-propanol

HRID 1266957노트

반응식

HRID 1266957 반응식
[CH:1]1([CH:13]=[O:14])[CH2:12][CH2:11][CH2:10][CH:9]=[CH:8][CH2:7][CH2:6][CH:5]=[CH:4][CH2:3][CH2:2]1.[CH:15]([Mg]Cl)([CH3:17])[CH3:16]>C1COCC1>[CH:1]1([CH:13]([OH:14])[CH:15]([CH3:17])[CH3:16])[CH2:12][CH2:11][CH2:10][CH:9]=[CH:8][CH2:7][CH2:6][CH:5]=[CH:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 54140259Cyclododeca-4,8-diene-1-carbaldehydeHCID 178418918HCID 178418918, 화합물

생성물 1

HCID 541109191-(4,8-Cyclododecadienyl)-2-methyl-1-propanol수율 65.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4,8-Cyclododecadiene carboxaldehyde (QRM 2185) [14.0 g; 0.072 mol] was dissolved in THF (50 ml), and isopropylmagnesium chloride [36 ml; 2.0 M in Et2O, 0.072 mol] was added dropwise with stirring under N2. The reaction mixture was stirred for 30 minutes, most solvent was removed in vacuo, and the residue quenched with saturated ammonium chloride solution, then partitioned (Et2O/H2O). The organic layer was separated, washed and dried over MgSO4. The solvent was removed in vacuo, and the residue was chromatographed [silica: Et2O 50%, hexane 50%] to give 1-(4,8-cyclododecadienyl)-2-methyl-1-propanol (11.1 g, 65%) as a colourless oil.

후처리

  1. stirringThe reaction mixture was stirred for 30 minutes
  2. custommost solvent was removed in vacuo
  3. customthe residue quenched with saturated ammonium chloride solution
  4. custompartitioned (Et2O/H2O)
  5. customThe organic layer was separated
  6. washwashed
  7. dry with materialdried over MgSO4
  8. customThe solvent was removed in vacuo
  9. customthe residue was chromatographed [silica: Et2O 50%, hexane 50%]

출처 및 근거

ORD 기록
ord-1a92c369d76f40aab6ce5a48e1ba8d4d
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06551988B1

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