Ethylene Glycol → 2-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

HRID 126736노트

반응식

HRID 126736 반응식
[OH:1][CH2:2][C:3](=[O:16])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[C:11](=[O:15])[CH2:12][CH2:13][CH:14]=1.[CH2:17](O)[CH2:18][OH:19].CC1C=CC(S(O)(=O)=O)=CC=1.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[CH2:18]1[O:19][C:11]2([CH2:12][CH2:13][CH:14]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3](=[O:16])[CH2:2][OH:1])[O:15][CH2:17]1

참가 물질

6

반응물 4

HCID 174Ethylene GlycolHCID 6101p-Toluenesulfonic acidHCID 516892Sodium BicarbonateHCID 202876282-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one

생성물 1

HCID 867375372-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 5.5 g. of 2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one (Example 88), 25 ml. of ethylene glycol, and 0.1 g. of P-toluenesulfonic acid in 200 ml. of toluene is reflucted for 40 minutes using a Dean-Stark trap. The solution is poured into saturated sodium bicarbonate. The mixture is extracted with benzene. The organic solution is washed three times with water and dried over magnesium sulfate. The solvent is removed to give 6.0 g. of the title compound.

후처리

  1. extractionThe mixture is extracted with benzene
  2. washThe organic solution is washed three times with water
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent is removed
  5. customto give 6.0 g

출처 및 근거

ORD 기록
ord-f49fcb853420467cba341134c29cc80e
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254036

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