Potassium Hydroxide → 3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid

HRID 1267626노트

반응식

HRID 1267626 반응식
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH:13]=[CH:14][C:15]([O:17]CC)=[O:16].[OH-].[K+]>C(O)C>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH:13]=[CH:14][C:15]([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 67200008Ethyl 3-(2,3,4-trimethoxyphenyl)prop-2-enoate

생성물 1

HCID 1184003-(2,3,4-Trimethoxyphenyl)-2-propenoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 3-(2,3,4-trimethoxyphenyl)propenoate (1.15 g) was dissolved in ethanol (20 mL), and to the solution 10% potassium hydroxide (1.21 g) was added, and the mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, water was added to the residue, and the mixture was adjusted to pH 2 with 2 M hydrochloric acid and extracted with ethyl acetate. The resultant organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure, water
  2. additionwas added to the residue
  3. extractionextracted with ethyl acetate
  4. dry with materialThe resultant organic layer was dried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ee355e4fcc944a8797892894afbb4c5a
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06552188B2

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