Ethanol → Ethyl 2-[4-(cyclopropanecarbonyl)phenyl]-2-methylpropanoate

반응식

[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13](N)=[O:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[CH2:18]([OH:20])[CH3:19]>>[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([O:20][CH2:18][CH3:19])=[O:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 702Ethanol

HCID 234998512-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

생성물 1

HCID 9813859Ethyl 2-[4-(cyclopropanecarbonyl)phenyl]-2-methylpropanoate

실험 절차

Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionamide (100 mg) in ethanol and bubble in hydrochloride gas for 5 minutes while stirring. Reflux for 10 hours, distill off the ethanol and extract into ethyl acetate. Evaporate the solvent in vacuo to give the title compound as an oil (50 mg).

후처리

custombubble in hydrochloride gas for 5 minutes
temperatureReflux for 10 hours
distillationdistill off the ethanol
extractionextract into ethyl acetate
customEvaporate the solvent in vacuo

출처 및 근거

ORD 기록: ord-23b529d3eb9b424d95165e73613c04ef
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06552200B2

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