Potassium Carbonate → 7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one

HRID 1267766노트

반응식

HRID 1267766 반응식
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21](Cl)=[O:22])=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:11][O:10][C:8]1[CH:9]=[C:2]2[C:3]([CH:4]=[C:20]([C:17]3[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=3)[C:21](=[O:22])[O:1]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 696002-Hydroxy-4-MethoxybenzaldehydeHCID 27346884-Methoxyphenylacetyl chloride

생성물 1

HCID 6889737-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one수율 89.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A suspension of 2-hydroxy-4-methoxybenzaldehyde (6.10 g), 4-methoxyphenylacetylchloride (11.1 g) and potassium carbonate (20 g) in acetone (400 ml) was heated under reflux for 2 hours. The reaction mixture was evaporated to remove the solvent, followed by addition of water. The resulting precipitates were collected by filtration and dried under reduced pressure to give 7-methoxy-3-(4-methoxyphenyl)-chromen-2-one (10.1 g, Yield 89%).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customThe reaction mixture was evaporated
  4. customto remove the solvent
  5. additionfollowed by addition of water
  6. customThe resulting precipitates
  7. filtrationwere collected by filtration
  8. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-f689324d1e8e4013bebc513e8b197ca4
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06552068B1

반응 노트

불러오는 중…