Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → Boc-DAla-Phe-Met-OCH3
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | BOC-D-alanine | HCID 637606 | — |
| 반응물 | H-Phe-Met-OMe.HCl | HCID 67685067 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Boc-DAla-Phe-Met-OCH3 | HCID 12888621 | 87% |
반응 단계
In an analogous fashion as described in Step A, 7.56 g of Boc-DAla-OH, 5.06 g of HOSu, 8.25 g of DCC, 13.8 ml of DIEA and the HCl salt above were allowed to react in 100 ml of DMF to give 16.67 g (87% of Boc-DAla-Phe-Met-OCH3, m.p. 109°-110° C., [α]D24.5 =-19.73° (c, 1.00 in methanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04254024 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-c85b515795834cc2a940d534e04c263d |
| 출처 메모 | uspto-grants-1981_03 |