2-Bromo-1-chloro-4-(trifluoromethoxy)benzene → 1-Chloro-2-vinyl-4-(trifluoromethoxy)benzene
반응식
Br[C:2]1[CH:7]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:4][C:3]=1[Cl:13].[CH2:14](C([Sn])=C(CCCC)CCCC)[CH2:15]CC>C1(C)C=CC=CC=1>[Cl:13][C:3]1[CH:4]=[CH:5][C:6]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:7][C:2]=1[CH:14]=[CH2:15]참가 물질
4
실험 절차
2-Bromo-1-chloro-4-(trifluoromethoxy)benzene (Description 25; 1.0 g, 3.6 mmol) and tri-n-butylvinyl tin (1.21 g, 3.8 mmol) were dissolved in toluene (20 mL) and the solution was degassed for 45 minutes with nitrogen. Tetrakis(triphenylphosphine) palladium (0) (100 mg) was then added and the solution heated at reflux for 2 hours. Once cooled, the solution was concentrated and the residue was purified by silica chromatography to give the title compound (274 mg, 1.2 mmol).
후처리
- customthe solution was degassed for 45 minutes with nitrogen
- additionTetrakis(triphenylphosphine) palladium (0) (100 mg) was then added
- temperaturethe solution heated
- temperatureat reflux for 2 hours
- temperatureOnce cooled
- concentrationthe solution was concentrated
- customthe residue was purified by silica chromatography
출처 및 근거
- ORD 기록
- ord-42516b6a83aa443da1d965425cf9656c
- 출처 데이터셋
- uspto-grants-2003_04
- 특허 번호
- US06555552B2
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