Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 5-Methoxy-o-toluidine | HCID 99500 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide | HCID 1132889 | — |
반응 단계
To a solution of 2-methyl-5-methoxyaniline (4.7 g) in tetrahydrofuran (50 ml), under nitrogen, was added diisopropylethylamine (12.6 ml) followed by dropwise addition of chloroacetyl chloride (2.7 ml) and the mixture stirred under nitrogen for 27 hours. The solution was poured into 2M aqueous hydrochloric acid (150 ml), extracted into diethyl ether (3×150 ml), washed with brine, dried (MgSO4), and concentrated to give the sub-title compound as a brown oil (5.15 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06555541B1 |
| 출처 데이터셋 | uspto-grants-2003_04 |
| ORD ID | ord-36a1ed5f78f94422bbb65456f266ec6b |
| 출처 메모 | uspto-grants-2003_04 |