Hydrochloric Acid → 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide

HRID 1267921

반응식

HRID 1267921 반응식
[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:3]=1[NH2:4].C(N(C(C)C)CC)(C)C.[Cl:20][CH2:21][C:22](Cl)=[O:23].Cl>O1CCCC1>[Cl:20][CH2:21][C:22]([NH:4][C:3]1[CH:5]=[C:6]([O:9][CH3:10])[CH:7]=[CH:8][C:2]=1[CH3:1])=[O:23]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 995005-Methoxy-o-toluidine

생성물 1

HCID 11328892-chloro-N-(5-methoxy-2-methylphenyl)acetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-methyl-5-methoxyaniline (4.7 g) in tetrahydrofuran (50 ml), under nitrogen, was added diisopropylethylamine (12.6 ml) followed by dropwise addition of chloroacetyl chloride (2.7 ml) and the mixture stirred under nitrogen for 27 hours. The solution was poured into 2M aqueous hydrochloric acid (150 ml), extracted into diethyl ether (3×150 ml), washed with brine, dried (MgSO4), and concentrated to give the sub-title compound as a brown oil (5.15 g).

후처리

  1. extractionextracted into diethyl ether (3×150 ml)
  2. washwashed with brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-36a1ed5f78f94422bbb65456f266ec6b
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06555541B1

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