Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloro-4-fluoroaniline → 2-(3-Chloro-4-fluorophenylamino)-N-(5-methoxy-2-methylphenyl)-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide | HCID 1132889 | — |
| 촉매 | Potassium Iodide | HCID 4875 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(3-Chloro-4-fluorophenylamino)-N-(5-methoxy-2-methylphenyl)-acetamide | HCID 18542413 | 86.7% |
반응 단계
2-Chloro-N-(5-methoxy-2-methylphenyl)-acetamide (3 g), 3-chloro4-fluoroaniline (7.56 g), diisopropylethylamine (13.8 ml), potassium iodide (0.005 g) and anhydrous tetrahydrofuran (20 ml) were heated together at 105° C. in a sealed tube for 19 hours. The mixture was then cooled and concentrated. Purification of the residue by silica gel chromatography (eluting with 1:1 iso-hexane/ethyl acetate) gave the sub-title compound (3.93 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06555541B1 |
| 출처 데이터셋 | uspto-grants-2003_04 |
| ORD ID | ord-5f5bdb6f7f7342ad9881942083b51512 |
| 출처 메모 | uspto-grants-2003_04 |