Maleic Anhydride → 6,10-Dihydroxy-4,12-dioctyl-3,13-dioxo-8-sulfoethyl-4,8,12-triaza-1,14-pentadecadiene-1,15-dicarboxylic acid

HRID 1268

반응식

HRID 1268 반응식
[OH:1][CH:2]([CH2:13][N:14]([CH2:28][CH2:29][S:30]([OH:33])(=[O:32])=[O:31])[CH2:15][CH:16]([OH:27])[CH2:17][NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:34]1(=[O:40])[O:39][C:37](=[O:38])[CH:36]=[CH:35]1>C1(C)C(C)=CC=CC=1>[OH:1][CH:2]([CH2:13][N:14]([CH2:28][CH2:29][S:30]([OH:33])(=[O:31])=[O:32])[CH2:15][CH:16]([OH:27])[CH2:17][N:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:34](=[O:40])[CH:35]=[CH:36][C:37]([OH:39])=[O:38])[CH2:3][N:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:34](=[O:40])[CH:35]=[CH:36][C:37]([OH:39])=[O:38]

참가 물질

4

반응물 2

HCID 7923Maleic AnhydrideHCID 5434780211,15-Dihydroxy-13-sulfoethyl-9,13,17-triazapentacosane

생성물 1

HCID 537323926,10-Dihydroxy-4,12-dioctyl-3,13-dioxo-8-sulfoethyl-4,8,12-triaza-1,14-pentadecadiene-1,15-dicarboxylic acid수율 80%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A reactor was charged with 20 g (0.04 mole) of 11,15-dihydroxy-13-sulfoethyl-9,13,17-triazapentacosane and 100 g of xylene, to which 10 g (0.1 mole) of maleic anhydride were then added with stirring to conduct a reaction at 50° C. for 6 hours. After xylene was distilled off under reduced pressure, 300 ml of water were added, and 10% sodium hydroxide was further added to keep the pH of the reaction mixture at 7. Thereafter, the reaction mixture was subjected to electrodialysis and lyophilized, thereby obtaining 22 g (isolation yield: 80%) of 6,10-dihydroxy-4,12-dioctyl-3,13-dioxo-8-sulfoethyl-4,8,12-triaza-1,14-pentadecadiene-1,15-dicarboxylic acid as white powder.

후처리

  1. additionwere then added
  2. customa reaction at 50° C. for 6 hours
  3. distillationAfter xylene was distilled off under reduced pressure, 300 ml of water
  4. additionwere added
  5. addition10% sodium hydroxide was further added

출처 및 근거

ORD 기록
ord-edde2bbf24c7456a8918ccba8422abf0
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723655

연결된 노트

불러오는 중…