Water → N-(4-aminophenyl)-2-hydroxybenzamide

HRID 1268034노트

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HRID 1268034 반응식
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:20])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1)(=O)C.C(=O)(O)[O-].[Na+].O.[Cl-].[Na+]>CO>[NH2:19][C:16]1[CH:15]=[CH:14][C:13]([NH:12][C:11](=[O:20])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[OH:4])=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 5234Sodium ChlorideHCID 516892Sodium BicarbonateHCID 18543278HCID 18543278, 화합물

생성물 1

HCID 2781453N-(4-aminophenyl)-2-hydroxybenzamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of 2-(4-aminophenylcarbamoyl)phenyl acetate (580 mg) in methanol (10 mL) is added saturated sodium bicarbonate (2 mL) and water (3 mL). The mixture is heated at 80° C. for 30 minutes, then poured into half-saturated aqueous sodium chloride and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oil which is then triturated with diethyl ether to provide the desired product as a white solid.

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate solution is dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customto give an oil which
  5. customis then triturated with diethyl ether

출처 및 근거

ORD 기록
ord-70ade6c842b4411ba45ac6c94bfbcf7b
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06555561B2

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