Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → HCID 58994162, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2-Bromo-6-methylpyridine | HCID 79205 | — |
| 반응물 | (2,4-Dimethoxypyrimidin-5-yl)boronic acid | HCID 2736209 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | HCID 58994162 | HCID 58994162 | 47.7% |
반응 단계
2,4-Di-methoxy-pyrimidine-5-boronic acid (500 mg, 2.72 mmol) was dissolved in degassed n-PrOH (40 mL) and then 2-bromo-6-methylpyridine (660 mg, 3.8 mmol), Na2CO3 (865 mg, 8.16 mmol), PPh3 (215 mg, 0.8 mmol) and Pd(OAc)2 (50 mg, 0.22 mmol) were added. The suspension was stirred at reflux for 4 hours. The solvent was evaporated and the crude was partitioned between water and Et2O. The organic phase was dried (Na2SO4) and evaporated. The crude was purified by flash chromatography with ethyl acetate-petroleum ether (2-8) to give 300 mg of the title compound (47% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727988B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-aee16765237f4c5d918624d6c4d3c6ad |
| 출처 메모 | uspto-grants-2010_06 |