Diisobutylaluminum hydride → (E)-3-(2',6'-dimethoxy-biphenyl-4-yl)-but-2-en-1-ol

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[C:11]1[CH:16]=[CH:15][C:14](/[C:17](/[CH3:24])=[CH:18]/[C:19](OCC)=[O:20])=[CH:13][CH:12]=1.CC(C[AlH]CC(C)C)C>>[CH3:10][O:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:11]1[CH:12]=[CH:13][C:14](/[C:17](/[CH3:24])=[CH:18]/[CH2:19][OH:20])=[CH:15][CH:16]=1

참가 물질

반응물 2

HCID 14487Diisobutylaluminum hydride

HCID 22557551HCID 22557551, 화합물

생성물 1

HCID 69802675(E)-3-(2',6'-dimethoxy-biphenyl-4-yl)-but-2-en-1-ol

실험 절차

(E)-Ethyl 3-(2′,6′-dimethoxy-biphenyl-4-yl)-but-2-enoate (0.90 g, 2.76 mmol) was reduced with DIBAL-H by a procedure analogous to that described in example 52b to give (E)-3-(2′,6′-dimethoxy-biphenyl-4-yl)-but-2-en-1-ol as a colourless solid; 0.82 g (100%).

출처 및 근거

ORD 기록: ord-d172975981114606bc60a3f64c78a617
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06555577B1

반응 노트

불러오는 중…