3,5-Bis-trifluoromethylphenylboronic acid → (E)-ethyl 3-(3',5'-bis-trifluoromethyl-biphenyl-4-yl)-but-2-enoate

HRID 1268310노트

반응식

HRID 1268310 반응식
I[C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[F:16][C:17]([F:32])([F:31])[C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1>>[F:16][C:17]([F:31])([F:32])[C:18]1[CH:19]=[C:20]([C:2]2[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=2)[CH:21]=[C:22]([C:24]([F:25])([F:26])[F:27])[CH:23]=1

참가 물질

3

반응물 2

HCID 1562653,5-Bis-trifluoromethylphenylboronic acidHCID 11438459(E)-ethyl 3-(4-iodophenyl)-but-2-enoate

생성물 1

HCID 22557698(E)-ethyl 3-(3',5'-bis-trifluoromethyl-biphenyl-4-yl)-but-2-enoate

실험 절차

The colourless solid, (E)-ethyl 3-(3′,5′-bis-trifluoromethyl-biphenyl-4-yl)-but-2-enoate was prepared from (E)-ethyl 3-(4-iodophenyl)-but-2-enoate (example 91a) and 3,5-bis-(trifluoromethyl)phenyl boronic acid by a procedure analogous to that described in example 91b.

출처 및 근거

ORD 기록
ord-a6ca2a1dc9ac4a6bad339b6e812e8a54
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06555577B1

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