Diisobutylaluminum hydride → (E)-3-(3',5'-dibromo-biphenyl-4-yl)-but-2-en-1-ol

반응식

CC(C[AlH]CC(C)C)C.[Br:10][C:11]1[CH:12]=[C:13]([C:18]2[CH:23]=[CH:22][C:21](/[C:24](/[CH3:31])=[CH:25]/[C:26](OCC)=[O:27])=[CH:20][CH:19]=2)[CH:14]=[C:15]([Br:17])[CH:16]=1>>[Br:10][C:11]1[CH:12]=[C:13]([C:18]2[CH:19]=[CH:20][C:21](/[C:24](/[CH3:31])=[CH:25]/[CH2:26][OH:27])=[CH:22][CH:23]=2)[CH:14]=[C:15]([Br:17])[CH:16]=1

참가 물질

반응물 2

HCID 14487Diisobutylaluminum hydride

HCID 22557684(E)-ethyl 3-(3',5'-dibromo-biphenyl-4-yl)-but-2-enoate

생성물 1

HCID 69800831(E)-3-(3',5'-dibromo-biphenyl-4-yl)-but-2-en-1-ol

실험 절차

The colourless gum (E)-3-(3′,5′-dibromo-biphenyl-4-yl)-but-2-en-1-ol was prepared by DIBAL-H reduction of (E)-ethyl 3-(3′,5′-dibromo-biphenyl-4-yl)-but-2-enoate as described for example 52b, with the purification of the product being carried out by preparative HPLC.

후처리

customas described for example 52b, with the purification of the product

출처 및 근거

ORD 기록: ord-60c23cb0f29f426db77f5286ca6c3195
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06555577B1

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