3,5-Dichlorophenylboronic acid → (E)-ethyl 3-(3',5'-dichloro-biphenyl-4-yl)-but-2-enoate

반응식

I[C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[C:21]([Cl:23])[CH:22]=1>>[Cl:16][C:17]1[CH:18]=[C:19]([C:2]2[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=2)[CH:20]=[C:21]([Cl:23])[CH:22]=1

참가 물질

반응물 2

HCID 27343313,5-Dichlorophenylboronic acid

HCID 11438459(E)-ethyl 3-(4-iodophenyl)-but-2-enoate

생성물 1

HCID 22557629(E)-ethyl 3-(3',5'-dichloro-biphenyl-4-yl)-but-2-enoate

실험 절차

The colourless solid (E)-ethyl 3-(3′,5′-dichloro-biphenyl-4-yl)-but-2-enoate was prepared from (E)-ethyl 3-(4-iodophenyl)-but-2-enoate (example 91a) and 3,5-dichlorobenzene boronic acid by a procedure analogous to that described in example 52a.

출처 및 근거

ORD 기록: ord-27948af550064940a7a14b4ce040b82a
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06555577B1

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