4-Bromoaniline → 1-(4-Bromophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

HRID 1268372노트

반응식

HRID 1268372 반응식
[C:1]1([C:7]([OH:9])=[O:8])([C:4](O)=[O:5])[CH2:3][CH2:2]1.[Br:10][C:11]1[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=1>C(#N)C>[Br:10][C:11]1[CH:17]=[CH:16][C:14]([N:15]2[CH2:3][CH2:2][CH:1]([C:7]([OH:9])=[O:8])[C:4]2=[O:5])=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 78074-BromoanilineHCID 690171,1-Cyclopropanedicarboxylic acid

생성물 1

HCID 35985231-(4-Bromophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

30 g of 1,1-cyclopropanedicarboxylic acid and 50 g of 4-bromoaniline were added to 50 ml of acetonitrile, followed by refluxing for 7 hours with heating and stirring.

후처리

  1. temperatureby refluxing for 7 hours
  2. temperaturewith heating

출처 및 근거

ORD 기록
ord-8eb52f9df5124485a74cf3eebb8e0392
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06555694B1

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