Thionyl Chloride → 1-Acetyl-4-piperidineacetyl chloride

HRID 126858노트

반응식

HRID 126858 반응식
S(Cl)([Cl:3])=O.[C:5]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:17])=O)[CH2:10][CH2:9]1)(=[O:7])[CH3:6]>>[C:5]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([Cl:3])=[O:17])[CH2:10][CH2:9]1)(=[O:7])[CH3:6]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 10442408(1-Acetylpiperidin-4-yl)acetic acid

생성물 1

HCID 202880651-Acetyl-4-piperidineacetyl chloride수율 95%

실험 절차

To 240 parts of thionyl chloride are added portionwise 25 parts of 1-acetyl-4-piperidineacetic acid and the whole is stirred overnight at room temperature. The reaction mixture is evaporated, yielding 26.5 parts (95%) of 1-acetyl-4-piperidineacetyl chloride as an oily residue.

후처리

  1. customThe reaction mixture is evaporated

출처 및 근거

ORD 기록
ord-6d0ab50928a64ba0a9220c1c4b1ab58e
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254127

반응 노트

불러오는 중…