Dichloromethane → 5-(3-Hydroxypropoxy)-2-nitrobenzaldehyde

3-Bromo-1-propanol (3.34 g, 24 mmol) was refluxed in 80 ml of anhydrous acetonitrile with 5-hydroxy-2-nitrobenzaldehyde (3.34 g, 20 mmol), K2CO3 (3.5 g), and KI (100 mg) overnight (15 h). The reaction mixture was cooled to room temperature and 150 ml of methylene chloride was added. The mixture was filtered and the solid residue was washed with methylene chloride. The combined organic solution was evaporated to dryness and redissolved in 100 ml methylene chloride. The resulted solution was washed with saturated NaCl solution and dried over sodium sulfate. 4.31 g (96%) of desired product was obtained after removal of the solvent in vacuo.

1. filtrationThe mixture was filtered
2. washthe solid residue was washed with methylene chloride
3. customThe combined organic solution was evaporated to dryness
4. dissolutionredissolved in 100 ml methylene chloride
5. washThe resulted solution was washed with saturated NaCl solution
6. dry with materialdried over sodium sulfate

ORD 기록

ord-127bd18b2dec482d97f77796524b0478

출처 데이터셋

uspto-grants-2007_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07198893B1