돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1268693생성일: 2026년 10월 26일

Epichlorohydrin → 2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

https://huagongshe.com/reaction/1268693

반응식

참여 물질

역할이름HCID투입량
반응물EpichlorohydrinHCID 7835—
반응물Potassium HydroxideHCID 14797—
반응물2-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridineHCID 22015659—
용매MethanolHCID 887—
용매DichloromethaneHCID 6344—
생성물2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridineHCID 22015632—

반응 단계

The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07199117B2
출처 데이터셋uspto-grants-2007_04
ORD IDord-5338b8c739c84f7abf4fbff8f8758892
출처 메모uspto-grants-2007_04