1-Phenethylamine, (-)- → HCID 67062310, 화합물

HRID 1268735노트

반응식

HRID 1268735 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([CH2:20][CH3:21])[S:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15](F)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[C:22]1([C@@H:28]([NH2:30])[CH3:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(=O)([O-])O.[Na+]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([CH2:20][CH3:21])[S:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:30][C@H:28]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:29])[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 758181-Phenethylamine, (-)-HCID 516892Sodium BicarbonateHCID 178629784-(3-Chlorophenyl)-2-ethyl-5-(2-fluoro-4-pyridyl)-1,3-thiazole

생성물 1

HCID 67062310HCID 67062310, 화합물수율 107.6%

반응 조건

온도
150 °C

실험 절차

A mixture of 4-(3-chlorophenyl)-2-ethyl-5-(2-fluoro-4-pyridyl)-1,3-thiazole (0.35 g, 1.1 mmol) and (S)-1-phenylethylamine (1.4 mL, 11 mmol) was stirred at 150° C. for 16 hrs. The reaction mixture was cooled to room temperature, saturated aqueous sodium hydrogen carbonate solution was added and the mixture was extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The obtained oil was treated with 10% hydrogen chloride-methanol to give the title compound (0.27 g, yield 56%).

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. concentrationconcentrated
  6. additionThe obtained oil was treated with 10% hydrogen chloride-methanol

출처 및 근거

ORD 기록
ord-495e3c80e77545efa9ccd6d17df3487f
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199124B2

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