Potassium Hydroxide → 2,4-Dimethylpyrimidine-5-carboxylic acid
반응식
[OH-].[K+].[CH3:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([C:11]([O:13]CC)=[O:12])=[CH:6][N:5]=1>C(O)C>[CH3:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([C:11]([OH:13])=[O:12])=[CH:6][N:5]=1참가 물질
4
실험 절차
A solution of potassium hydroxide (67 g, 1.0 mol) in 95% ethanol (300 mL) was added to a solution of ethyl 2,4-dimethyl-5-pyrimidinecarboxate (73 g, 0.40 mol) in 95% ethanol (100 mL) and the mixture was heated under reflux for 5 hrs. Ethanol was evaporated under reduced pressure, and the residue was dissolved in water, and the aqueous solution was acidified with conc. hydrochloric acid. Precipitated solids were collected by filtration, washed with water and dried to give the title compound (36 g, yield 58%).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux for 5 hrs
- customEthanol was evaporated under reduced pressure
- dissolutionthe residue was dissolved in water
- customPrecipitated solids
- filtrationwere collected by filtration
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-5482ea86e6e7451f991255e3056c5869
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07199124B2
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