Methanesulfonyl chloride → HCID 10456186, 화합물

HRID 1268795노트

반응식

HRID 1268795 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:22]2[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[N:15]=[C:14]([NH2:23])[C:13]=2[N:12]=[C:11]1[CH2:24][CH2:25][CH2:26][CH3:27].[CH3:28][S:29](Cl)(=[O:31])=[O:30]>>[NH2:23][C:14]1[C:13]2[N:12]=[C:11]([CH2:24][CH2:25][CH2:26][CH3:27])[N:10]([CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][S:29]([CH3:28])(=[O:31])=[O:30])[C:22]=2[C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N:15]=1

참가 물질

3

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 223444481-(8-Aminooctyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine

생성물 1

HCID 10456186HCID 10456186, 화합물수율 48.2%

실험 절차

Using the general method of Example 242, 1-(8-aminooctyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (1.2 g, 3.26 mmol) was reacted with methanesulfonyl chloride (260 μL, 3.26 mmol) to provide 0.70 g of N-[8-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)octyl]methanesulfonamide as a tan powder, m.p. 121–124° C. Analysis: Calculated for C23H35N5O3S: % C, 61.99: % H, 7.92; % N, 15.72. Found: % C, 62.01; % H, 7.97; % N, 15.75.

출처 및 근거

ORD 기록
ord-9995a3ad5ee742e885698f3c8e517e24
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199131B2

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