Cesium carbonate → 2-(4-Nitrophenyl)isothiazolidine 1,1-dioxide

HRID 1268818노트

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HRID 1268818 반응식
C(=O)([O-])[O-].[Cs+].[Cs+].[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH2:20][CH2:21][CH2:22]Cl)(=[O:19])=[O:18])=[CH:12][CH:11]=1)([O-:9])=[O:8]>C(#N)C>[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:22][CH2:21][CH2:20][S:17]2(=[O:19])=[O:18])=[CH:12][CH:11]=1)([O-:9])=[O:8]

참가 물질

4

반응물 2

HCID 10796Cesium carbonateHCID 17988807N-(4-nitrophenyl)-3-chloropropane-1-sulfonamide

생성물 1

HCID 184468302-(4-Nitrophenyl)isothiazolidine 1,1-dioxide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
70 °C

실험 절차

13.0 g (40.0 mmol) of caesium carbonate are added to a solution of 7.40 g (26.6 mmol) of N-(4-nitrophenyl)-3-chloropropane-1-sulfonamide in 150 ml of acetonitrile, and the mixture is stirred at 70° C. for 18 hours. The reaction mixture is subjected to conventional work-up, and the crude product is chromatographed on a silica-gel column using ethyl acetate/petroleum ether as eluent, giving 2-(4-nitrophenyl)isothiazolidine 1,1-dioxide as a yellowish solid; ESI 243.

후처리

  1. customthe crude product is chromatographed on a silica-gel column

출처 및 근거

ORD 기록
ord-64fdfc45f6914ad981de0c7ea0a8efba
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199133B2

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