5-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine → 5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione

HRID 12691노트

반응식

HRID 12691 반응식
[CH3:1][C:2]1[O:3][C:4]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[C:5]([CH3:7])[N:6]=1>CO>[CH3:1][C:2]1[O:3][C:4]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[C:5]([CH3:7])[N:6]=1

참가 물질

3

반응물 1

HCID 589942085-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine

생성물 1

HCID 589942315-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione수율 92.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 5-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine (Prep61, 600 mg, 2.5 mmol) in MeOH (40 mL) 2N HClaq (10 mL) was added. After refluxing the mixture for 3 hours, the solvents were evaporated. The crude was triturated with acetone and filtered to give 480 mg of 5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione as a light brown powder (92% yield)

후처리

  1. temperatureAfter refluxing the mixture for 3 hours
  2. customthe solvents were evaporated
  3. customThe crude was triturated with acetone
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-10572850b6114d11ba0fe37e22948765
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727988B2

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