Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Tert-butyl 3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | tert-butyl N-(3-bromopropyl)carbamate | HCID 4460490 | — |
| 반응물 | Acetamide, N-[3-(4-piperidinyl)phenyl]- | HCID 22048943 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Tert-butyl 3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propylcarbamate | HCID 22049023 | 43.1% |
반응 단계
A mixture of N-[3-(4-piperidyl)phenyl]acetamide (550 mg, 2.1 mmol), tert-butyl 3-bromopropylcarbamate (550 mg, 2.3 mmol), K2CO3 (1.10 g, 8.9 mmol), diisopropylethyl amine (1.50 mL) and a few crystals of KI in dioxane (20 mL) was heated at reflux temperature for 2 days. The precipitated salts were removed by filtration, the filtrate was concentrated in vacuo and the crude product was chromatographed on silica to give the desired product (340 mg; 43%): ESMS m/e: 376.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07199135B2 |
| 출처 데이터셋 | uspto-grants-2007_04 |
| ORD ID | ord-b7ccb9d402e441a3b0e6c73cee3131b0 |
| 출처 메모 | uspto-grants-2007_04 |