N-(3-{1-[5-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)pentyl]4-piperidinyl}phenyl)-2-methylpropanamide → N-{3-[1-(3-amino propyl)4-piperidinyl]phenyl}acetamide

참여 물질

역할	이름	HCID	투입량
반응물	N-(3-{1-[5-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)pentyl]4-piperidinyl}phenyl)-2-methylpropanamide	HCID 16757160	—
반응물	N-(3-{1-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)ethyl]4-piperidinyl}phenyl)-2-methylpropanamide	HCID 16757361	—
반응물	N-(3-{1-[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)propyl]-4-piperidinyl}phenyl)-2-methylpropanamide	HCID 16757362	—
반응물	N-(3-{1-[4-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-yl)Butyl]-4-Piperidinyl}Phenyl)-2-Methylpropanamide	HCID 16757363	—
반응물	N-(3-{1-[6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamide	HCID 16757364	—
생성물	N-{3-[1-(3-amino propyl)4-piperidinyl]phenyl}acetamide	HCID 21957249	—

반응 단계

Using the methods described above, the following additional intermediates were synthesized. N-(3-{1-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE. ESMS m/e: 420.2 (M+H)+. N-(3-{1-[3-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE: ESMS m/e: 434.4 (M+H)+. N-(3-{1-[4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE: ESMS m/e: 448.4 (M+H)+. N-(3-{1-[5-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PENTYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE. ESMS m/e: 462.4 (M+H)+. N-(3-{1-[6-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)HEXYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE: ESMS m/e: 476.4 (M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07199135B2
출처 데이터셋	uspto-grants-2007_04
ORD ID	ord-8af05fc719a54c86abcd64157aa15ba4
출처 메모	uspto-grants-2007_04