HCID 18448528, 화합물 → HCID 69431308, 화합물

HRID 1269464노트

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HRID 1269464 반응식
[N:1]1([CH2:7][C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[CH:16]([NH:20][C:21](=[O:42])[CH2:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][N:24]2[S:29]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=2)(=[O:31])=[O:30])[CH2:15][CH2:14][CH2:13]3)=[CH2:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CCO>[CH3:9][C@@H:8]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[C@H:16]([NH:20][C:21](=[O:42])[CH2:22][C@@H:23]1[CH2:28][CH2:27][CH2:26][CH2:25][N:24]1[S:29]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:40])([F:41])[F:39])[CH:33]=1)(=[O:31])=[O:30])[CH2:15][CH2:14][CH2:13]2)[CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 1

HCID 18448528HCID 18448528, 화합물

생성물 1

HCID 69431308HCID 69431308, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of N-[6-(1-piperidin-1-ylmethyl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-2-[1-(3-trifluoromethyl-benzenesulfonyl)-piperidin-2-yl]-acetamide (34 mg, 0.05 mmol), EtOH (2 mL), Pd/Al2O3 (Johnson Matthey, 12 mg, 0.1 eq) was purged with H2 and connected to a H2 balloon for 30 min at RT. The catalyst was filtered through Celite and washed with MeOH. The filtrate was concentrated in vacuo. The crude was purified by silica gel chromatography (7%–10% MeOH—CH2Cl2) to afford the title compound as a mixture of two diastereomers. MS (ESI): 606 (M+H)+. Calc'd for C32H42F3N3O3S—605.29.

후처리

  1. customwas purged with H2
  2. filtrationThe catalyst was filtered through Celite
  3. washwashed with MeOH
  4. concentrationThe filtrate was concentrated in vacuo
  5. customThe crude was purified by silica gel chromatography (7%–10% MeOH—CH2Cl2)

출처 및 근거

ORD 기록
ord-c17da065b3424feb896129c29e10fce1
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199244B2

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