Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Hydroxypyridine → 3-Pyridyl 4-(hexadecylamino)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Hydroxypyridine | HCID 7971 | — |
| 반응물 | 4-(Hexadecylamino)benzoic acid | HCID 47263 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 촉매 | Sodium hydride | HCID 24758 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Pyridyl 4-(hexadecylamino)benzoate | HCID 23457762 | — |
반응 단계
A 6 g. (16.6 m moles) sample of 4-(hexadecylamino)-benzoic acid and 2.7 g. (16.6 m moles) 1,1'-carbonyldiimidazole in 50 ml. dry tetrahydrofuran is stirred for 2 hours. Then, 1.58 g. (16.6 m moles) 3-hydroxypyridine and a trace of sodium hydride catalyst is added and the reaction is refluxed for 3 hours. The solution is cooled, filtered, and evaporated. The product is crystallized from isopropanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04254138 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-e6f52b2215cc4e8487b9559907b6b9e9 |
| 출처 메모 | uspto-grants-1981_03 |