2,4,6-Tribromophenol → HCID 18448747, 화합물

HRID 1269574

반응식

HRID 1269574 반응식
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[OH:10].F[C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[Br:8][C:6]1[CH:7]=[C:2]([Br:1])[C:3]([O:10][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)=[C:4]([Br:9])[CH:5]=1

참가 물질

5

반응물 3

HCID 14832,4,6-TribromophenolHCID 9590p-FluoronitrobenzeneHCID 10796Cesium carbonate

생성물 1

HCID 18448747HCID 18448747, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A stirred solution of 2,4,6-tribromophenol (3.8 g), 4-fluoronitrobenzene (1:6 g), cesium carbonate (3.7 g) in dimethylformamide (8 mL) was heated at reflux until the starting materials were consumed. The reaction was cooled to room temperature and concentrated. The residue was dissolved in ethyl acetate and washed with sodium hydroxide (2 N), hydrochloric acid (2 N) and brine. Concentration of the organic phase gave 1,3,5-tribromo-4-(4-nitrophenoxy)benzene in quantitative yield. The crude product was used directly in the next step.

후처리

  1. temperatureat reflux until the starting materials
  2. customwere consumed
  3. concentrationconcentrated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. washwashed with sodium hydroxide (2 N), hydrochloric acid (2 N) and brine

출처 및 근거

ORD 기록
ord-f7d8a15e89044a28844d345b9cd75f4f
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199265B2

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