Sodium Methoxide → HCID 18448749, 화합물

HRID 1269575노트

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HRID 1269575 반응식
[CH3:1][O-:2].[Na+].[Br:4][C:5]1[CH:6]=[C:7](F)[CH:8]=[C:9]([Br:21])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=1>CN(C)C=O>[Br:4][C:5]1[CH:6]=[C:7]([O:2][CH3:1])[CH:8]=[C:9]([Br:21])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 18448750HCID 18448750, 화합물

생성물 1

HCID 18448749HCID 18448749, 화합물수율 52.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Sodium methylate (2.2 g) was added to a solution of 3,5-dibromo-4-(4-nitrophenoxy)fluorobenzene (10 g) and dimethylformamide (25 mL). The reaction mixture was heated at 100° C. for 15 minutes. After cooling down to room temperature, concentration and purification on column (silica gel, ethyl acetate/petrolium ether, 1:9), 5.4 g of 3,5-dibromo-4-(4-nitrophenoxy)anisole was obtained.

후처리

  1. temperatureAfter cooling down to room temperature
  2. concentrationconcentration and purification on column (silica gel, ethyl acetate/petrolium ether, 1:9)

출처 및 근거

ORD 기록
ord-289924d7c3824c9a9a8b49e1d9137819
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199265B2

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