Ethanol → HCID 86592347, 화합물

HRID 1269577노트

반응식

HRID 1269577 반응식
[C:1]([O:4][O:5][C:6]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)=[C:8]([Br:23])[C:7]=1[CH2:24][CH3:25])(=[O:3])[CH3:2].C(O)C>C(OC(=O)C)C.Cl[Zn]Cl>[C:1]([O:4][O:5][C:6]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)=[C:8]([Br:23])[C:7]=1[CH2:24][CH3:25])(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 702EthanolHCID 86592346HCID 86592346, 화합물

생성물 1

HCID 86592347HCID 86592347, 화합물수율 88.9%

시약·촉매·용매 2

HCID 5727Zinc Chloride촉매HCID 8857Ethyl Acetate용매2회

실험 절차

Ethyl(3,5-dibromo-4-[4-nitrophenoxy]phenoxy) acetate (2.4 g), zink chloride (5.7 g), ethylacetate (30 mL) and ethanol (30 mL) was heated at reflux for two hours. After cooling down to room temperature, the reaction mixture was diluted with ethylacetate, washed with a saturated aqueous solution of sodium hydrogencarbonate and the organic phase dried over potassium carbonate. After concentration, 2.0 g of ethyl(3,5-dibromo-4-[4-aminophenoxy]phenoxy) acetate was obtained as a brown oil.

후처리

  1. temperatureat reflux for two hours
  2. washwashed with a saturated aqueous solution of sodium hydrogencarbonate
  3. dry with materialthe organic phase dried over potassium carbonate
  4. concentrationAfter concentration

출처 및 근거

ORD 기록
ord-22611691b7884236bb529b6a2835dc8c
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199265B2

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