Sulfuric Acid → HCID 86737540, 화합물

HRID 126995노트

반응식

HRID 126995 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH:15]([C:16]([OH:18])=[O:17])[CH2:14][C:13]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][C:25](=[CH2:27])[CH3:26].S(=O)(=O)(O)O>CCOCC>[CH2:1]([O:8][C:9]([N:11]1[CH:15]([C:16]([O:18][C:25]([CH3:27])([CH3:26])[CH3:24])=[O:17])[CH2:14][C:13]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 20288724(+/-)-4,5-Dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid

생성물 1

HCID 86737540HCID 86737540, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 6.6 g of (±)-4,5-dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, 5 ml of isobutylene, 25 ml of ether and 0.25 ml of concentrated sulfuric acid is shaken in a pressure vessel for about 16 hours. The reaction vessel is vented (-10° C.) and the contents are washed with ice cold aqueous sodium hydroxide. The organic fraction is dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title compound.

후처리

  1. custom(-10° C.)
  2. washthe contents are washed with ice cold aqueous sodium hydroxide
  3. dry with materialThe organic fraction is dried over anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-6b242c2ec9d541f9baf79fab80cb00b6
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254267

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