HCID 86737540, 화합물 → (+/-)-4,5-Dihydro-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester

HRID 126996노트

반응식

HRID 126996 반응식
C(OC([N:11]1[CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:14][C:13]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[N:12]1)=O)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[S:24]1[CH:25]=[CH:26][CH:27]=[C:23]1[C:13]1[CH2:14][CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[NH:11][N:12]=1

참가 물질

5

반응물 2

HCID 86737540HCID 86737540, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 86737541(+/-)-4,5-Dihydro-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 5.0 g of (±)-4,5-dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester in 75 ml of ethanol containing 0.5 g of 5% palladium on carbon is hydrogenated at atmospheric pressure until the uptake of hydrogen ceases. The catalyst is removed by filtration through Celite and the filtrate is concentrated in vacuo to yield the title compound.

후처리

  1. customThe catalyst is removed by filtration through Celite
  2. concentrationthe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-6f0aff55b685477b9f9edbd03f8521a5
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254267

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