Triethylamine → 40316-56-1

HRID 1270053노트

반응식

HRID 1270053 반응식
[C:1]1([C:7]#[C:8]/[CH:9]=[CH:10]/[CH2:11]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.CS([Cl:24])(=O)=O>ClCCl>[Cl:24][CH2:11]/[CH:10]=[CH:9]/[C:8]#[C:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 546319840317-08-6

생성물 1

HCID 546319740316-56-1수율 82.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of (E)-5-phenyl-pent-2-en-4-yn-1-ol (Method 1b) (4.9 g, 31.0 mmol) and triethylamine (3.8 g, 38.0 mmol) in dry dichloromethane (200 mL) was added methanesulfonyl chloride (3.8 g, 33 mmol) dropwise. Stirring was continued at room temperature overnight. The reaction mixture was concentrated in vacuo and the residue washed with heptane/dichloromethane (×2) to give 4.5 g (82%) crude (E)-(5-chloro-pent-3-en-1-ynyl)-benzene.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. washthe residue washed with heptane/dichloromethane (×2)

출처 및 근거

ORD 기록
ord-e6b9acc0a27c4c0bb64667f7c3c712e3
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202213B2

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