HCID 18449243, 화합물 → HCID 18449207, 화합물
반응식
O[CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[C:8]([NH:17][CH:18]([CH3:20])[CH3:19])[C:9]3[N:10]2[C:13](=[O:16])[NH:14][N:15]=3)=[CH:5][CH:4]=1.[H][H]>CCO.[Pd]>[CH:18]([NH:17][C:8]1[C:9]2[N:10]([C:13](=[O:16])[NH:14][N:15]=2)[C:11]2[C:6]([N:7]=1)=[CH:5][CH:4]=[C:3]([CH3:2])[CH:12]=2)([CH3:20])[CH3:19]참가 물질
5
실험 절차
A solution of 8-hydroxymethyl-4-isopropylamino-2H-[1,2,4]triazolo[4,3-a]quinoxalin-1-one (20 mg) in EtOH (15 mL) was treated 10% Pd/C (10 mg), and the mixture was agitated under 45 psi hydrogen atmosphere for 68 hrs. The reaction mixture was filtered through diatomaceous earth, the filtrate concentrated, and the residue purified by silica gel chromatography to provide the title compound as a solid. MS (M+H)+=258.0.
후처리
- filtrationThe reaction mixture was filtered through diatomaceous earth
- concentrationthe filtrate concentrated
- customthe residue purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-6eeba0f51812498f9e3e908452c97232
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07202245B2
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