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Potassium Carbonate → 5,7-dimethyl-2-(4-nitrophenyl)-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-4-amine

HRID 1270307
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HRID 1270307 반응식
[CH3:1][C:2]1[N:3]=[C:4]([CH3:25])[N:5]2[C:10]=1[C:9]([N:11]1[CH:15]=NC=N1)=[N:8][C:7]([C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=1)=[N:6]2.[CH3:26][O:27][C:28]1[CH:29]=C([CH:32]=[C:33]([O:37][CH3:38])[C:34]=1[O:35][CH3:36])N.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][C:2]1[N:3]=[C:4]([CH3:25])[N:5]2[C:10]=1[C:9]([NH:11][C:15]1[CH:29]=[C:28]([O:27][CH3:26])[C:34]([O:35][CH3:36])=[C:33]([O:37][CH3:38])[CH:32]=1)=[N:8][C:7]([C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=1)=[N:6]2
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참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 322853,4,5-TrimethoxyanilineHCID 22329661HCID 22329661, 화합물

생성물 1

HCID 223296435,7-dimethyl-2-(4-nitrophenyl)-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-4-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
90 °C

실험 절차

A solution of 130 mg (0.39 mmol) of 5,7-dimethyl-2-(4-nitrophenyl)-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine from example 11A in DMF is treated with 111 mg (0.58 mmol) of 3,4,5-trimethoxyaniline and 80 mg (0.58 mmol) of potassium carbonate. The reaction mixture is stirred overnight at 90° C. After cooling, the solvent is removed on a rotary evaporator, the residue is treated twice more with toluene and the solvent is removed in vacuo again. The product is extracted by stirring with a little methanol and filtered off with suction.

후처리

  1. temperatureAfter cooling
  2. customthe solvent is removed on a rotary evaporator
  3. additionthe residue is treated twice more with toluene
  4. customthe solvent is removed in vacuo again
  5. extractionThe product is extracted
  6. stirringby stirring with a little methanol
  7. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-c52b4b7684444567ae8b57e4e107d823
출처 데이터셋
uspto-grants-2007_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07202243B2

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