Morpholine → 4-(2,6-Difluoro-4-nitrophenyl)morpholine

HRID 1270334노트

반응식

HRID 1270334 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1F>C(#N)C>[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1[N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 27827931,2,3-Trifluoro-5-nitrobenzene

생성물 1

HCID 223856304-(2,6-Difluoro-4-nitrophenyl)morpholine수율 88%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Morpholine (1.2 g, 14.12 mmol) was added to a stirring solution of 3,4,5-trifluoronitro benzene (1 g, 5.65 mmol) in acetonitrile (15 mL) and the reaction mixture was refluxed for 5 h. A viscous liquid was obtained upon concentration, which was then poured into crushed ice. The solid thus obtained was filtered off and dried under reduced pressure to obtain the title compound (1.2 g, 88%).

후처리

  1. temperaturethe reaction mixture was refluxed for 5 h
  2. customA viscous liquid was obtained upon concentration, which
  3. additionwas then poured
  4. custominto crushed ice
  5. customThe solid thus obtained
  6. filtrationwas filtered off
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-d95740646ca04af786232cafb0cbef43
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202254B2

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