Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Thiosulfate → 1-Phenylcyclohexane-1-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Thiosulfate | HCID 24477 | — |
| 반응물 | Isocyanate | HCID 105034 | — |
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Phenylcyclohexane-1-carbaldehyde | HCID 14922606 | 150.3% |
반응 단계
To compound 2 (5.0 g, 26.3 mmol) in CH2Cl2 (50 mL) was added 13.4 g (31.6 mmol) of Dess-Martin periodinane. After 2 h, sodium thiosulfate (58 g) followed by sat. NaHCO3 (200 mL) was added. After stirring for 1 h, the reaction mixture was diluted with EtOAc then washed with H2O, brine and dried over anhydrous sodium sulfate. Purification by flash chromatography (3:1, hexane-EtOAc) gave 1-phenyl-cyclohexanecarbaldehyde (4.47 g, 90%) as a colorless oil. Mass Spec [M+H]+=189.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07202253B2 |
| 출처 데이터셋 | uspto-grants-2007_04 |
| ORD ID | ord-66d2f3378244432dbc4e79256408d4f6 |
| 출처 메모 | uspto-grants-2007_04 |