Phenylurea → 2-Phenyl-1,2,4-thiadiazolidine-3,5-dione

참여 물질

반응 단계

To the solution of phenyl-urea (13.0 g, 95.48 mol) in THF (100 mL) was slowly added chlorocarbonyl sulfenylchloride (13 mL, 148.85 mmol) at RT. The reaction mixture was refluxed overnight, the volatiles removed in vacuo yielded 2-phenyl-1,2,4-thiadiazolidine-3,5-dione as a white solid (4.0 g, 20%). 1H NMR (DMSO-d6): δ 12.49 (s, 1H), 7.51 (d, J=8.0 Hz, 2H), 7.43 )t, J=7.6 Hz, 2H), 7.27 (t, J=7.2 Hz, 1H).

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