Iodobenzene → 5-(4-methylphenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole

반응식

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[NH:5][N:4]=1.I[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:18]1([N:5]2[C:6]([C:8]3[CH:9]=[CH:10][C:11]([CH3:14])=[CH:12][CH:13]=3)=[CH:7][C:3]([C:2]([F:1])([F:15])[F:16])=[N:4]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

반응물 2

HCID 11575Iodobenzene

HCID 178423762HCID 178423762, 화합물

생성물 1

HCID 103350645-(4-methylphenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole

실험 절차

This compound was isolated by silica gel chromatography following arylation of 3-trifluoromethyl-5-(p-tolyl)-1H pyrazole using iodobenzene as described in Example 1.1.

후처리

customThis compound was isolated by silica gel chromatography

출처 및 근거

ORD 기록: ord-c2b94ff6d22b49e3b3abe423ec635dec
출처 데이터셋: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07202367B2

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