2,3,5,6-Tetrafluoroaniline → 4-Bromo-2,3,5,6-tetrafluoroaniline

HRID 1270710

반응식

HRID 1270710 반응식
[F:1][C:2]1[C:8]([F:9])=[CH:7][C:6]([F:10])=[C:5]([F:11])[C:3]=1[NH2:4].[Br:12]Br.C(=O)(O)[O-].[Na+]>CO>[F:1][C:2]1[C:8]([F:9])=[C:7]([Br:12])[C:6]([F:10])=[C:5]([F:11])[C:3]=1[NH2:4]

참가 물질

5

반응물 3

HCID 127862,3,5,6-TetrafluoroanilineHCID 24408BromineHCID 516892Sodium Bicarbonate

생성물 1

HCID 6186714-Bromo-2,3,5,6-tetrafluoroaniline

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2,3,5,6-Tetrafluoroaniline (25.0 g, 0.15 mol) is dissolved in methanol (100 mL) and treated with elemental bromine (28.4 g, 0.17 mol) by dropwise addition at room temperature. Solid sodium bicarbonate (15 g, 0.18 mol) is added portionwise and the resulting mixture stirred for an additional 2 hours. The reaction mixture is partitioned between Et2O (500 mL) and water (1000 mL). The organic layer is dried (MgSO4) and evaporated by a rotary evaporator to give 2,3,5,6-tetrafluoro-4-bromoaniline (m.p. 59–60° C.).

후처리

  1. customThe reaction mixture is partitioned between Et2O (500 mL) and water (1000 mL)
  2. dry with materialThe organic layer is dried (MgSO4)
  3. customevaporated by a rotary evaporator

출처 및 근거

ORD 기록
ord-906efc43d8134ab7bf0efa1ae004ddbb
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202364B2

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