참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | N-(6-fluoro-2-naphthyl)carbamic acid ethyl ester | HCID 68804469 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | N-(1-chloro-6-fluoro-2-naphthyl)carbamic acid ethyl ester | HCID 68805760 | — |
반응 단계
A mixture of N-(6-fluoro-2-naphthyl)carbamic acid ethyl ester (548 mg, 2.35 mmol), N-chlorosuccinimide (313 mg, 2.35 mmol) and 1 M HCl in acetic acid (2.35 mL, 2.35 mmol) in acetic acid (20 mL) is heated at 50° C. under N2 atmosphere for 1 hour. After cooling to room temperature, water (10 mL) is added. The resulting precipitate is removed by filtration to give N-(1-chloro-6-fluoro-2-naphthyl)carbamic acid ethyl ester as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07202364B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_04 |
|---|
| ORD ID | ord-815e20b22aa64a378644eda4b27f66cb |
|---|
| 출처 메모 | uspto-grants-2007_04 |
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