Potassium Hydroxide → 1-Chloro-6-fluoro-2-aminonaphthalene

HRID 1270769노트

반응식

HRID 1270769 반응식
C(OC(=O)[NH:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:16])[CH:12]=2)[C:7]=1[Cl:17])C.[OH-].[K+]>C(O)C>[Cl:17][C:7]1[C:8]2[C:13](=[CH:12][C:11]([F:16])=[CH:10][CH:9]=2)[CH:14]=[CH:15][C:6]=1[NH2:5]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 68805760N-(1-chloro-6-fluoro-2-naphthyl)carbamic acid ethyl ester

생성물 1

HCID 184514831-Chloro-6-fluoro-2-aminonaphthalene

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of N-(1-chloro-6-fluoro-2-naphthyl)carbamic acid ethyl ester (600 mg, 2.24 mmol) and KOH (1.51 g, 26.9 mmol) in ethanol (20 mL) is heated to reflux temperature under N2 atmosphere for 12 hours. After cooling, the reaction mixture is concentrated by rotary evaporator. The residual oil is purified by flash chromatography on silica gel (3:1 hexanes/EtOAc) to give 1-chloro-6-fluoro-2-aminonaphthalene as a brown solid.

후처리

  1. temperatureis heated
  2. temperatureto reflux temperature under N2 atmosphere for 12 hours
  3. temperatureAfter cooling
  4. concentrationthe reaction mixture is concentrated by rotary evaporator
  5. customThe residual oil is purified by flash chromatography on silica gel (3:1 hexanes/EtOAc)

출처 및 근거

ORD 기록
ord-99f366b8e9874aa299d46b023460aedf
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202364B2

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