참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 2,3-Butanediamione, 2,3-dimethyl- | HCID 123390 | — |
| 반응물 | 2-Amino-5-bromo-3-methylpyridine | HCID 137934 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Iodo-3-methylpyridin-2-amine | HCID 959586 | 93% |
반응 단계
To dioxane (10 mL) was added 5-bromo-3-methylpyridin-2-amine (2 g, 10.6 mmol), sodium iodide (3.2 g, 21.4 mmoL), copper iodide (0.190 g, 1.06 mmol) and the solution degassed followed by addition of tetramethylethane-1,2-diamine (0.803 mL, 1.06 mmol) this mixture heated at 110° C. overnight. After cooling water was added and extracted the crude product with ethyl acetate. The residue was purified by column chromatography to give 5-iodo-3-methylpyridin-2-amine as a beige solid (2.3 g, 93%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07205296B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_04 |
|---|
| ORD ID | ord-43d6e3a73cb3456fbaf97377735b77fa |
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| 출처 메모 | uspto-grants-2007_04 |
|---|
