Potassium Hydroxide → [2-(2,2,2-Trifluoroacetamido)-1,3-thiazol-4-yl]acetic acid

HRID 127106노트

반응식

HRID 127106 반응식
[OH-].[K+].[F:3][C:4]([F:20])([F:19])[C:5]([NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=1)=[O:6]>O>[F:20][C:4]([F:3])([F:19])[C:5]([NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=1)=[O:6]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 2303713T0501-6206

생성물 1

HCID 20288638[2-(2,2,2-Trifluoroacetamido)-1,3-thiazol-4-yl]acetic acid수율 66.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of potassium hydroxide (4.2 g.) in water (100 ml.) was added ethyl 2-trifluoroacetamidothiazol-4-ylacetate (14.1 g.) at room temperature with stirring, and the mixture was stirred for 1 hour at room temperature. After the reaction, the reaction mixture was washed with ethyl acetate and adjusted to about pH 3 with 10% hydrochloric acid under ice-cooling and stirring. The precipitated solid was collected by filtration and dried over phosphorus pentoxide to give 2-trifluoroacetamidothiazol-4-ylacetic acid (8.5 g.), mp 117°-120° C.

후처리

  1. stirringthe mixture was stirred for 1 hour at room temperature
  2. customAfter the reaction
  3. washthe reaction mixture was washed with ethyl acetate
  4. temperaturecooling
  5. stirringstirring
  6. filtrationThe precipitated solid was collected by filtration
  7. dry with materialdried over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-b0cafa0395c9484f8220e7fb4a5ce7ef
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254260

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